This study aims to describe the numerical modeling and nonlinear finite element analysis of typical spinal braces as a first step towards optimizing their topology for 3D printing.Numerical simulation was carried out in Abaqus CAE software Version 2021, utilizing a CAD (Meshmixer Version 3.5.474) scan of an actual spinal brace.Boundary conditions w
Towards halal pharmaceutical: Exploring alternatives to animal-based ingredients
Halal is a crucial concept for Muslim consumers regarding consumed products, including pharmaceutical ingredients, which are essential in modern medicine.To address the issue of using porcine-sourced ingredients in pharmaceuticals, it is essential to search for halal alternatives derived from poultry, animal by-products from meat processing, marine
Understanding Lateral Marsh Edge Erosion with Terrestrial Laser Scanning (TLS)
Coastal wetlands are a crucial buffer zone between land and sea but lateral erosion threatens their long-term sustainability.Better understanding of the forces leading to lateral marsh retreat Hand Balm will benefit the assessment of management options applied to mitigate the erosion.Terrestrial Laser Scanning (TLS), Light Detection and Ranging (li
High glucose inhibits ClC-2 chloride channels and attenuates cell migration of rat keratinocytes
Fuqiang Pan, Rui Guo, Wenguang Cheng, Linlin Chai, Wenping Wang, Chuan Cao, Shirong LiDepartment of Plastic and Reconstructive Surgery, Southwestern Hospital, Third Military Medical University, Chongqing, People’s Republic of China Background: Accumulating evidence has demonstrated that migration of keratinocytes is critical to wound epitheli
Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells.
New therapies are needed for metastatic breast cancer patients.Oncolytic herpes simplex virus (oHSV) is an exciting therapy being developed for use against aggressive tumors and established metastases.Although oHSV have been demonstrated safe in clinical trials, a lack of sufficient potency has slowed the clinical application of this approach.We ut